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  • Title: Rectified Brownian motion and kinesin motion along microtubules.
    Author: Fox RF, Choi MH.
    Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2001 May; 63(5 Pt 1):051901. PubMed ID: 11414927.
    Abstract:
    The mechanism of rectified Brownian movement is used to analyze measured data for kinesin motion along microtubules. A key component of the mechanism is the diffusive movement of the microtubule binding heads of kinesin during the adenosine triphosphate (ATP) cycle. The first-passage time distribution for this step is analyzed in detail and is shown to be responsible for observed load-velocity profiles. The ATPase activity of the kinesin heads is that of a nucleotide switch and not that of a direct chemomechanical energy converter. Experimental data acquisition, rate constants, and alternative explanations are discussed. The mechanism described in this paper is fundamental to the nanobiology of intracellular processes.
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