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  • Title: Northwest African distribution of the CD4/Alu microsatellite haplotypes.
    Author: Flores C, Maca-Meyer N, González AM, Cabrera VM.
    Journal: Ann Hum Genet; 2000 Jul; 64(Pt 4):321-7. PubMed ID: 11415516.
    Abstract:
    We have analysed a linked microsatellite/Alu polymorphism at the CD4 locus (CD4/Alu) in 666 chromosomes from samples of the Iberian Peninsula, Northwest Africa, and West sub-Saharan Africa. The Iberian Peninsula differs from other European populations by its higher levels of haplotype diversity (0.75), and weaker association between the microsatellite allele 90 and Alu(-) chromosomes. These results are explainable by a substantial gene flow from Northwest Africa. Significant geographic clines for the five major haplotypes suggest a south to north migration from sub-Saharan Africa into Northwest Africa. In spite of this, the consistent presence of haplotype 110(-) in this area is congruent with an ancient and autochthonous human presence in Northwest Africa.
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