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  • Title: [Glaucomatous optic neuropathy: a reperfusion injury].
    Author: Flammer J.
    Journal: Klin Monbl Augenheilkd; 2001 May; 218(5):290-1. PubMed ID: 11417319.
    Abstract:
    BACKGROUND: We introduce a pathogenetic concept which explains the present known clinical and experimental facts. MATERIALS AND METHODS: The known clinical risk factors for glaucomatous optic neuropathy as well as the outcomes of the experimental studies were systematically collected. RESULTS: IOP fluctuations are more damaging than a stable increased IOP, reduced circulation due to vascular dysregulation is more damaging than reduced circulation due to arteriosclerosis and the glaucomatous damage is clearly different from a pure ischemic lesion. CONCLUSIONS: Although IOP can damage mechanically, IOP fluctuation and blood pressure drops may lead to short term ischemia, followed by a reperfusion damage. A vascular dysregulation interferes with the autoregulation of ocular perfusion and renders the eye more sensitive to IOP increase or blood pressure decrease.
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