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  • Title: Vasorelaxing effect of the potassium (K+)-channel opener pinacidil in isolated porcine ciliary arteries.
    Author: Morf T, Zhu P, Flammer J, Haefliger IO.
    Journal: Klin Monbl Augenheilkd; 2001 May; 218(5):338-40. PubMed ID: 11417330.
    Abstract:
    PURPOSE: The aim of this study was to investigate the vasorelaxing properties of pinacidil (a potassium-channel-opener) in isolated porcine ciliary arteries. METHODS: Isometric contractions of isolated porcine ciliary arteries were measured with a myograph system. The vessels were first precontracted with the thromboxane A2 analog U 46619 (0.1 microM), and then exposed, in a cumulative manner, to increasing concentrations of pinacidil (1 nM-100 microM). Relaxations have been expressed in percent of the maximal contraction evoked by U 46619 (0.1 microM). RESULTS: Pinacidil showed a pronounced concentration-dependent relaxing effect in isolated porcine ciliary arteries. The difference between pinacidil and time-control experiments was significant (100 microM: 112 +/- 2% vs. 18 +/- 6%, P < 0.0001). The half-maximal concentration (pD50) value was 5.3 +/- 0.1 (-log M). CONCLUSIONS: The present study indicates that pinacidil has marked vasorelaxing properties in isolated porcine ciliary arteries.
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