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  • Title: Synthesis of novel 2,4 (1H, 3H)-quinazolinedione derivatives with analgesic and anti-inflammatory activities.
    Author: Baraka MM.
    Journal: Boll Chim Farm; 2001; 140(2):90-6. PubMed ID: 11417393.
    Abstract:
    Starting from mefenamic acid a series of 1-(2,3-dimethyl-phenyl)-2,4(1H,3H)-quinazolinedione derivatives were prepared. Structures of the new compounds were confirmed by microanalysis, IR, and 1H-NMR. Seven representative compounds were subjected to preliminary pharmacological screening which revealed that some of them exhibited analgesic and anti-inflammatory activity greater than mefenamic acid.
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