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  • Title: Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
    Author: Kalauni SK, Choudhary MI, Shaheen F, Manandhar MD, Atta-ur-Rahman, Gewali MB, Khalid A.
    Journal: J Nat Prod; 2001 Jun; 64(6):842-4. PubMed ID: 11421762.
    Abstract:
    Two new steroidal alkaloids, (-)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3 beta-(senecioylamino)-5 alpha-pregn-16-en-4 beta-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3 beta-(tigloylamino)-5 alpha-pregn-16-en-2 beta,4 beta-diacetate], were isolated from the leaves of Sarcococca coriacea. Their structures were elucidated on the basis of their spectral properties. Compounds 1 and 2 were found to be cholinesterase inhibitors.
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