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  • Title: Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia.
    Author: Ito T, Yamadera H, Ito R, Suzuki H, Asayama K, Endo S.
    Journal: Psychiatry Clin Neurosci; 2001 Jun; 55(3):281-2. PubMed ID: 11422876.
    Abstract:
    The present study investigated the effects of vitamin B12 (VB12) on circadian rhythm in Alzheimer-type dementia (ATD). Twenty-eight ATD patients were treated with bright light therapy (BLT) for 8 weeks. For the latter 4 weeks, half were treated with VB12 with BLT (BLT + VB12). We evaluated the cognitive state with Mini-Mental State Examination and the circadian rhythm with actigraphy after the fourth and eighth week. After the first 4 weeks BLT improved the circadian rhythm disturbances and cognitive state especially in the early stage of ATD. Although the latter 4 week-BLT caused no significant effects on the circadian rhythm; BLT + VB12 improved the vigilance level during the daytime. These results suggest that VB12 has some efficiency to enhance vigilance for ATD patients.
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