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Title: T-gamma gene rearrangement and CMV mononucleosis. Author: Mathew P, Hudnall SD, Elghetany MT, Payne DA. Journal: Am J Hematol; 2001 Jan; 66(1):64-6. PubMed ID: 11426498. Abstract: A clonal T-gamma rearrangement was found in peripheral blood and bone marrow in a 57-year-old female who presented with 6-week history of fevers, night sweats, and weight loss. Splenomegaly, hemolytic anemia, atypical lymphocytosis, a marrow lymphoid aggregate, and elevated LDH had suggested lymphoproliferative disease. However, IgM serology for cytomegalovirus (CMV) was positive. With observation alone, her clinical features improved over 4 weeks with normalization of the blood count and disappearance of CMV viremia and the aberrant T-gamma clone. Acute CMV infection may mimic lymphoproliferative disease. T-gamma gene rearrangement may be part of the immune response to CMV infection and is not specific to lymphoid neoplasia.[Abstract] [Full Text] [Related] [New Search]