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  • Title: Increase of isoprostane 8-epi-PGF(2alpha)after restarting smoking.
    Author: Chehne F, Oguogho A, Lupattelli G, Budinsky AC, Palumbo B, Sinzinger H.
    Journal: Prostaglandins Leukot Essent Fatty Acids; 2001 Jun; 64(6):307-10. PubMed ID: 11427039.
    Abstract:
    Isoprostanes are known as reliable markers of in vivo oxidation injury. Cigarette smoking has been shown to be associated with a significant increase in 8-epi-PGF(2alpha), a major member of this family of compounds. Quitting smoking reduces 8-epi-PGF(2alpha) values to normal within a couple of weeks only. In this follow-up we checked the 8-epi-PGF(2alpha), values in plasma, serum and urine in 28 people who restarted smoking after a quitting attempt of various duration. 8-epi-PGF(2alpha)shows a certain increase after restarting smoking reaching a maximum after already 1 week. Continuation of smoking does not significantly further increase 8-epi-PGF(2alpha). These data indicate a fast response of restarting as on quitting smoking on in vivo oxidation injury. The oxidation injury reflected by 8-epi-PGF(2alpha)may be a key pathogenetic mechanism in smoking-induced vascular injury.
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