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  • Title: Is the re-closure of surgically induced open neural tube defect the repetition of primary neurulation? An experimental study with chick embryos.
    Author: Chung SK, Sim KB, Cho BK, Hong SK, Wang KC.
    Journal: Neurosci Lett; 2001 Jul 13; 307(2):69-72. PubMed ID: 11427302.
    Abstract:
    It is well known that surgically induced open neural tube defects (ONTDs) tend to re-close in early embryonic stages. To investigate whether the process of re-closure is a repetition of primary neurulation, the morphological changes of surgically induced ONTDs were chronologically examined in early chick embryos. Longitudinal incisions of 3-somite length were made in the neural tubes of chick embryos at Hamburger and Hamilton stage 18 or 19. About half of the embryos showed complete closure of the skin on surgical microscopic examination. The re-closed neural tubes showed no remarkable differences from the controls on histological examination. The process of re-closure involved a zipper-like (ventral to dorsal) closure in the transverse sections of neural tubes. The results indicate that the re-closure of surgically induced ONTDs does not repeat the process of natural primary neurulation.
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