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  • Title: The biology of Epstein-Barr virus in post-transplant lymphoproliferative disease.
    Author: Hsieh WS, Lemas MV, Ambinder RF.
    Journal: Transpl Infect Dis; 1999 Sep; 1(3):204-12. PubMed ID: 11428990.
    Abstract:
    Post-transplant lymphoproliferative disease (PTLD) is a B cell proliferative disorder that is associated with Epstein-Barr virus (EBV), an ubiquitous herpesvirus. EBV-seronegative organ transplant recipients are at highest risk. EBV infection in PTLD lesions exists in a latent rather than lytic state, making tumor regression in response to antiviral agents unlikely. Viral latency proteins drive proliferation of T cells but also allow T cells to target PTLD lesions for destruction. Augmentation of the cellular immune response via the infusion of EBV-specific cytotoxic T cells has yielded promising results in the prevention and treatment of PTLD in bone marrow transplant recipients. Efforts to extend this strategy to solid organ transplant recipients are ongoing.
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