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  • Title: Short-Term prophylaxis with ceftriaxone plus metronidazole in esophageal cancer surgery.
    Author: Ruol A, Bertiato G, Boscarin S, Cusinato R, Pascarella M, Tonin EA, Santi S, Ancona E.
    Journal: J Chemother; 2000 Sep; 12 Suppl 3():23-8. PubMed ID: 11432679.
    Abstract:
    An open prospective study was carried out in 82 consecutive patients undergoing resective surgery for esophageal cancer from January 1995 to July 1996. Antimicrobial prophylaxis was done using a single dose of ceftriaxone (2 g i.v.) given at the induction of anesthesia in combination with metronidazole (0.5 g i.v.). Two further doses of metronidazole were administered 8 and 16 hours postoperatively. Fourteen patients (17%) experienced postoperative infections. This study, even though open and non-comparative, confirms that ceftriaxone given as a single-dose plus metronidazole provides adequate prophylaxis and significant cost-savings in comparison with multiple-dose prophylactic regimens in patients undergoing major surgery for esophageal cancer. Furthermore, the single-dose regimen reduces the workload for the nursing staff, the risk of side effects, and the possibility of selecting resistant strains.
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