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  • Title: [Disorders in gaze saccades in Huntington disease. Clinical correlations].
    Author: Garcia Ruiz P, Fontán A, Cenjor C, Ulmer E, Gomez Tortosa E, Sanchez Pernaute R, Rojo A, Garcia de Yébenes J.
    Journal: Nervenarzt; 2001 Jun; 72(6):437-40. PubMed ID: 11433702.
    Abstract:
    Oculomotor abnormalities have long been recognized in Huntington's disease (HD). The precise correlation between them and other clinical findings has not yet been determined. Using videonystagmography, we studied reflexive, visually guided horizontal saccades in 32 patients with genetically confirmed HD: nine female and 23 male patients, including six with young onset HD (YOHD), 19 with adult onset HD (AOD), and seven with late onset HD (LOHD). Huntington's patients exhibited increased saccade latency (P < 0.05), decreased saccade velocity (P < 0.0005), and impaired saccade accuracy (P < 0.01). A significant difference between the different groups of patients could be determined, and YOHD was characterized by normal latency and decreased saccade velocity while LOHD showed increased saccade latency but normal velocity. Furthermore, we found a significant difference between the genetic data (length of CAG-repeats) and saccadic abnormalities, with higher repeat numbers corresponding to shorter latency and decreased velocity, as in YOHD. The study of saccade parameters might be useful as an objective method for testing the effectiveness of future therapies.
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