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  • Title: Reference intervals for the markers of proteinuria with a standardised bed-rest collection of urine.
    Author: Kouri T, Harmoinen A, Laurila K, Ala-Houhala I, Koivula T, Pasternack A.
    Journal: Clin Chem Lab Med; 2001 May; 39(5):418-25. PubMed ID: 11434392.
    Abstract:
    Reference intervals for markers of proteinuria or glomerular charge selectivity were measured in 61 healthy female and 61 healthy male individuals. Timed bed-rest and daytime collections were used to assess significance of preanalytical variability of results. Bed-rest collections are advisable for research on renal damage, whereas in routine care, robust protein/creatinine ratios work as practical estimates of protein excretion rates, the correlations to excretion rates improving with increasing proteinuria. For glomerular charge selectivity, pancreatic/salivary isoamylase clearance ratio showed lower within-subject biological variation than IgG/IgG4 clearance ratio, allowing more accurate classification into normal and reduced charge selectivity. With our method, the lower 2.5% reference intervals for isoamylase clearance ratio were 1.1 in men and 1.9 in women.
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