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  • Title: Poly(ADP-ribosyl)ation of transcription factor Yin Yang 1 under conditions of DNA damage.
    Author: Oei SL, Shi Y.
    Journal: Biochem Biophys Res Commun; 2001 Jul 06; 285(1):27-31. PubMed ID: 11437367.
    Abstract:
    Under conditions of severe DNA damage the nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is activated, catalyzing the modification of proteins by forming and attaching to them poly(ADP-ribose) chains. A specific physical interaction between PARP-1 and transcription factor Yin Yang 1 (YY1) in vitro was shown previously, which had important consequences for the activities of both proteins. It is demonstrated here that YY1 and PARP-1 form complexes in vivo. YY1 was transiently poly(ADP-ribosyl)ated immediately after genotoxic treatment of HeLa cells. The narrow time frame of the modification coincides with that known for the activation of PARP-1 under these conditions. This immediate modification correlated with a decreased affinity of YY1 to its cognate DNA binding sites.
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