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  • Title: Effect of selection for increased body weight in turkeys on lymphoid organ weights, phagocytosis, and antibody responses to fowl cholera and Newcastle disease-inactivated vaccines.
    Author: Li Z, Nestor KE, Saif YM, Anderson JW, Patterson RA.
    Journal: Poult Sci; 2001 Jun; 80(6):689-94. PubMed ID: 11441833.
    Abstract:
    The influence of selection was studied for increased 16-wk BW in turkeys on in vivo phagocytic activity, antibody responses to vaccines, and weight of the spleen and bursa of Fabricius. A line (F) of turkeys selected long term for increased 16-wk BW and its corresponding randombred control (RBC2) were compared. Phagocytic activity was evaluated by the carbon clearance assay. Antibody responses to inactivated Newcastle disease virus and Pasteurella multocida vaccines were examined by ELISA. Body weight and relative weights of spleen and bursa of Fabricius of the two lines were also compared. The F line had lower phagocytic activity than the RBC2 line (P < 0.05). In addition, the F line had greater BW, relative weight of spleen, and ratio of spleen to bursa of Fabricius weight (P < 0.01) but had a lower relative weight of bursa of Fabricius at 9 wk of age. However, there were no line differences in the antibody responses to Newcastle disease virus or P. multocida vaccines at 1, 2, 3, 4, 5, or 12 wk after vaccination. Based on the present results, it is suggested that long-term selection for increased 16-wk BW might have resulted in changes in the immune system, as indicated by changes in the relative weights of the spleen and bursa of Fabricius and phagocytic activity. The decreased phagocytic activity in the F line may be partially responsible for increased susceptibility to specific diseases in this line.
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