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  • Title: Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease.
    Author: Liu HC, Hong CJ, Liu CY, Lin KN, Tsai SJ, Liu TY, Chi CW, Wang PN.
    Journal: Psychiatry Clin Neurosci; 2001 Aug; 55(4):427-9. PubMed ID: 11442897.
    Abstract:
    A significant increase of 267C allele of the 5-HT(6) receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers for evidence of depression using a Chinese version of the Standard Clinical Interview for DSM-III-R. The difference in the 5-HT(6) genotype or allele distributions between the AD patients with depressive disorders (n = 25) and those without (n = 120) was not significant.
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