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  • Title: Report of three cases of circulating heparin-like anticoagulants.
    Author: Llamas P, Outeiriño J, Espinoza J, Santos AB, Román A, Tomás JF.
    Journal: Am J Hematol; 2001 Aug; 67(4):256-8. PubMed ID: 11443639.
    Abstract:
    Clinically significant endogenous circulating heparin-like anticoagulant activity has been associated with hematological malignancies, liver damage, and other pathological conditions. The source of high plasma concentrations of endogenous heparin-like anticoagulants is poorly understood. We report three cases of circulating heparin-like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T-prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxis and deep-site hematoma to bleeding of biopsy site and occasional ecchymosis.
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