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  • Title: [Insertion-deletion polymorphism of the serotonin carrier gene and evaluation of neurotism as a temperament trait in patients with affective disorders and mentally healthy people].
    Author: Golimbet VE, Alfimova VM, Shcherbatykh TV, Abramova LI, Kaleda VG, Rogaev EI.
    Journal: Mol Biol (Mosk); 2001; 35(3):397-400. PubMed ID: 11443919.
    Abstract:
    Some studies associate the insertion/deletion polymorphism of the serotonin transporter (5-HTT) gene with anxiety-related personality traits in mentally healthy people, the short (s) allele being associated with a higher neuroticism score. The 5-HTT genotype and neuroticism score were established for 114 affective patients, 87 healthy relatives of endogenous psychosis patients, and for 156 mentally healthy people without familial psychiatric history. The effects of sex and age on the association between the two parameters was studied. Neuroticism proved to be not associated with the 5-HTT genotype.
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