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Pubmed for Handhelds

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  • Title: Unchanged sensitivity to electric shock in L-tryptophan treated rats.
    Author: Hole K, Marsden CA.
    Journal: Pharmacol Biochem Behav; 1975; 3(2):307-9. PubMed ID: 1144487.
    Abstract:
    Injections of L-tryptophan (50, 100 and 200 mg/kg) i.p. in rats resulted in dose dependent increases in brain concentrations of tryptophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Sensitivity to electric shock as measured by flinch and jump thresholds was not changed by L-tryptophan 100 and 200 mg/kg. The results indicate that increased 5-HT turnover does not influence sensitivity to electric shock.
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