These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of bile acid preparations on DNA biosynthesis, apoptosis, and necrosis in hepatocytes in vitro].
    Author: Danchenko EO.
    Journal: Vopr Med Khim; 2001; 47(2):236-42. PubMed ID: 11450444.
    Abstract:
    Using primary culture of hepatocytes it was shown that glycochenodeoxycholic acid (GCDCA) in a dose dependent manner induces apoptosis or necrosis of the hepatocytes and inhibits DNA biosynthesis. Ursodeoxycholic acid (UDCA) and tauroursodexycholic acid (TUDCA) do not cause apoptosis or necrosis of the hepatocytes in a range of doses 25-400 micrograms/ml. But in the presence of GCDCA both preparations have an antiapoptosogenic effect and TUDCA has also an antinecrosogenic effect.
    [Abstract] [Full Text] [Related] [New Search]