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  • Title: [Significance of argyrophilic proteins of the nucleolar organizer region in differentiation of benign and malignant growth of thyroid epithelial tumors].
    Author: Bukaeva IA, Smirnova EA, Pavlovskaia AI, Makanin MA, Ol'khovskaia IG, Raĭkhlin NT.
    Journal: Arkh Patol; 2001; 63(3):15-8. PubMed ID: 11452646.
    Abstract:
    Argyrophilic proteins of nucleolar organizers (NO) were measured in 47 benign (24 follicular and 8 atypical adenomas) and malignant (8 papillary and 7 follicular carcinomas) tumors. The content of argyrophilic NO proteins was significantly higher in malignant cells. The proportion of cells with at least 5 silver grains per cell was 16.8 and 22.8% in follicular and papillary carcinoma, respectively, and 3.2 and 12% in follicular and atypical adenoma, respectively. These data can be used as accessory signs in differential diagnosis.
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