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  • Title: Inhibitory effects of maesanin and analogs on arachidonic acid metabolizing enzymes.
    Author: Abourashed EA, Muhammad I, Resch M, Bauer R, el-Feraly FS, Hufford CD.
    Journal: Planta Med; 2001 Jun; 67(4):360-1. PubMed ID: 11458456.
    Abstract:
    The substituted 1,4-benzoquinone, maesanin (1), is a potent 5-lipoxygenase (5-LO) inhibitor present in the fruit of Maesa lanceolata Forssk. Thirteen natural, synthetic, semisynthetic, and microbially transformed analogs of 1 were tested for their in vitro inhibition of 5-lipoxygenase (5-LO) and cyclooxygenase-1 (COX-1). Maesanin was the most active 5-LO inhibitor. All other analogs were inactive or less active than the natural products as 5-LO inhibitors. None of the tested compounds was strongly active in the COX-1 inhibition assay.
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