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  • Title: [Count, proliferation and differentiation potential of hematopoietic stem cells chronically exposed to radiation].
    Author: shibkova DZ, Efimova NV, Akleev AV.
    Journal: Radiats Biol Radioecol; 2001; 41(3):295-300. PubMed ID: 11458643.
    Abstract:
    The paper presents the results of experimental studies on the kinetics and proliferative potential of hemopoietic stem cells in CBA-line mice under the conditions of chronic gamma-exposure at a dose rate of 0.16 Gy/day until the cumulative dose of 43.2 Gy was reached. It was possible based on the exo-colonization test to trace the status of the stem pool in the bone marrow and spleen. The study included an assessment of the proliferative and differentiating potentials of CFUs in the hemopoiesis components of interest. The observations conducted at late times of chronic radiation exposure (at days 180-270) allowed to identify a new status of the hemopoietic system which is characterized by activation of CFUs proliferation and redistribution of cell subpopulations at differentiation stage.
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