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  • Title: Synthesis and biological evaluation of didemnin photoaffinity analogues.
    Author: Vera MD, Pfizenmayer AJ, Ding X, Ahuja D, Toogood PL, Joullié MM.
    Journal: Bioorg Med Chem Lett; 2001 Jul 23; 11(14):1871-4. PubMed ID: 11459650.
    Abstract:
    The synthesis of four benzophenone-containing analogues of the antiproliferative natural product didemnin B is presented. In vitro protein biosynthesis inhibition potency and antitumor activity were evaluated. The results indicate that all four analogues are biologically active and could serve as photoaffinity reagents for the study of receptor-binding interactions of didemnins. These analogues could also be useful in studying antitumor effects of didemnins.
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