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  • Title: Nicotinamide N-oxides as CXCR2 antagonists.
    Author: Cutshall NS, Ursino R, Kucera KA, Latham J, Ihle NC.
    Journal: Bioorg Med Chem Lett; 2001 Jul 23; 11(14):1951-4. PubMed ID: 11459668.
    Abstract:
    A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.
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