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  • Title: Serum levels of elastin-derived peptides in patients with ruptured and asymptomatic abdominal aortic aneurysms.
    Author: Petersen E, Gineitis A, Wågberg F, Angquist KA.
    Journal: Eur J Vasc Endovasc Surg; 2001 Jul; 22(1):48-52. PubMed ID: 11461103.
    Abstract:
    OBJECTIVE: to determine whether serum elastin-derived peptides (S-EDP), are lower in patients with ruptured abdominal aortic aneurysms (rAAA) than asymptomatic (aAAA). MATERIALS AND METHODS: serum samples were collected preoperatively from 45 consecutive patients with aAAA and 15 haemodynamically stable patients with rAAA. S-EDP (ng/ml) was measured by a competitive enzyme-linked immunosorbent assay (ELISA). RESULTS: S-EDP (mean +/- s.d.) was significantly lower in patients with rAAA (31.6 ng/ml +/- 6.8) than in patients with aAAA (39.4 ng/ml +/- 8.0 p=0.001). CONCLUSION: patients with rAAA had significantly lower levels of S-EDP than patients with aAAA. The possibility that S-EDP can be used to identify patients at increased risk of rupture requires further investigation.
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