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  • Title: Protective effect of docosahexaenoic acid against retinal ischemic injury: an electroretinographic study.
    Author: Miyauchi O, Mizota A, Adachi-Usami E, Nishikawa M.
    Journal: Ophthalmic Res; 2001; 33(4):191-5. PubMed ID: 11464070.
    Abstract:
    PURPOSE: To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS: Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) was given 5 h before the ischemia. Electroretinograms were recorded just before the ischemia and at 60-min intervals up to 4 h after circulation was restored. RESULTS: The ratio of the amplitudes after the ischemia to that just before ischemia was significantly higher in eyes administered DHA-E than in controls at each time point (p < 0.01). CONCLUSION: DHA-E is effective in protecting the retina against transient retinal ischemia.
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