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  • Title: Growth hormone and nutrition as protective agents against methotrexate induced enteritis.
    Author: Ortega M, de Segura IA, Vázquez I, López JM, De Miguel E.
    Journal: Rev Esp Enferm Dig; 2001 Mar; 93(3):148-55. PubMed ID: 11469075.
    Abstract:
    OBJECTIVE: To determine whether exogenously administered growth hormone can reduce or prevent chemotherapy-induced intestinal mucosa injury. The expected results will allow to consider its potential clinical use. DESIGN: Experimental and randomized study. SETTING: Experimental Surgery Service, La Paz University Hospital. SUBJECTS: Adult Wistar rats weighing 250-300 g. MATERIALS AND METHODS: A chemotherapy protocol with methotrexate (MTX) (120 mg/kg) was employed. Animals fed either with a normoproteic or a hyperproteic liquid diet were treated with either saline or growth hormone (1 mg/kg/day) since three days before until four days after chemotherapy. Animals were sacrificed seven days after MTX administration for tissue sampling. RESULTS: Co-administration of growth hormone and a hyperproteic diet increased intestinal crypt proliferation and reduced MTX-induced apoptosis. CONCLUSIONS: Jejunal mucosal structure (morphometry), proliferation (Ki-67) and apoptosis (TUNNEL) were assessed.
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