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  • Title: Immunomodulative effects of aflatoxins and selenium on human natural killer cells.
    Author: Methenitou G, Maravelias C, Athanaselis S, Dona A, Koutselinis A.
    Journal: Vet Hum Toxicol; 2001 Aug; 43(4):232-4. PubMed ID: 11474740.
    Abstract:
    The possible immunomodulative effects of aflatoxin B1 and selenium (as sodium selenite) at concentrations lower than 5.10(-11) M or 0.05ppb and 10(-5) M, respectively on natural killer (NK) cells from healthy volunteers were evaluated by a 51Cr release natural killer assay. Aflatoxin B1 and selenium separately had an immunosuppressive effect on NK cell activity. When they were studied in combination, they caused a statistically significant increase of the cytotoxic activity of NK cells in the presence of the lowest concentrations of aflatoxin B1 (0.005ppb) and of sodium selenite (10(-8)M).
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