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  • Title: Botulinum toxin type A (BOTOX) for treatment of migraine.
    Author: Binder WJ, Brin MF, Blitzer A, Pogoda JM.
    Journal: Semin Cutan Med Surg; 2001 Jun; 20(2):93-100. PubMed ID: 11474749.
    Abstract:
    An open-label study and 2 double-blind, placebo-controlled studies have provided supporting evidence of botulinum toxin type A (BTX-A) as an effective, well-tolerated treatment for migraine. Observed durations of benefit were consistent with known properties of BTX-A. Findings suggest that response may vary by features of preinjection headaches, such as migraine frequency. The precise mechanism by which BTX-A provides pain relief is hypothesized to be related not only to acetylcholine inhibition but also to a blocking action on the parasympathetic nervous system. Additional studies that control factors likely to be related to response may lead to better understanding of the BTX-A effect on migraine and an optimal treatment protocol.
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