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  • Title: Preventing experimental vertical transmission of scrapie by embryo transfer.
    Author: Wang S, Foote WC, Sutton DL, Maciulis A, Miller JM, Evans RC, Holyoak GR, Call JW, Bunch TD, Taylor WD, Marshall MR.
    Journal: Theriogenology; 2001 Jul 15; 56(2):315-27. PubMed ID: 11480623.
    Abstract:
    This study investigated whether the transmission of naturally occurring scrapie in sheep can be prevented using embryo transfer. Embryos were collected from 38 donor ewes in a Suffolk sheep flock with a high incidence of naturally occurring scrapie, treated with a sanitary procedure (embryo washing) recommended by the International Embryo Transfer Society and then transferred to 58 scrapie-free recipient ewes. Ninety-four offspring were produced. None of the offspring or the recipient ewes developed scrapie. Furthermore, offspring derived from embryos collected from donor ewes bred to the immunohistochemically positive ram did not develop scrapie. We conclude that scrapie was not transmitted to offspring via the embryo nor was the infective agent transmitted to recipient ewes during embryo transfer procedures.
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