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Title: TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556. Author: Sasaki T, Igarashi Y, Saito N, Furumai T. Journal: J Antibiot (Tokyo); 2001 May; 54(5):441-7. PubMed ID: 11480888. Abstract: Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7'-demethylnovobiocin and 5"-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria.[Abstract] [Full Text] [Related] [New Search]