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  • Title: Microsurgical reanastomosis of rabbit oviduct and its functional and pathological sequelae.
    Author: Winston RM.
    Journal: Br J Obstet Gynaecol; 1975 Jul; 82(7):513-22. PubMed ID: 1148136.
    Abstract:
    A microsurgical technique for anastomosis of the oviduct is described using the rabbit as an animal model. A control group of five previously sterilized rabbits had both oviducts rejoined and all became pregnant. Another three groups of animals had a reanastomosis immediately after division of both oviducts. One oviduct was later removed for histological study and the animals were subsequently mated. Twenty-three out of 25 (92 per cent) conceived and delivered a normal litter after repair of the oviduct with very fine nylon sutures without postoperative splinting; only seven out of 15 (46.7 per cent) delivered after catgut sutures had been used without splinting and only 9 out of 20 (45 per cent) delivered when nylon sutures and prolonged splinting were associated with increased fibrosis, adhesion formation and poor healing of the anastomosis. Using the rabbit as an animal model, a microsurgical technique for reanastomosis of the oviduct is described. 5 previously sterilized rabbits had both oviducts rejoined by this technique (used on Group 1), and all animals became pregnant. 3 other groups of rabbits underwent reanastomosis immediately following oviductal division. Another operation was then performed to remove 1 oviduct for histological study. These 3 groups of animals were mated. 3 oviductal resection techniques were performed: 1) use of very fine nylon sutures without postoperative splinting; 2) use of catgut sutures without splinting; and 3) use of nylon sutures combined with 7 days of oviduct splinting postoperatively. In Group 1, 92% (23 of 25) animals conceived and delivered after repair. In Group 2, 46.7% (7 of 15) delivered. In Group 3, 9 of 20 animals (45%) delivered. Not only was Method 1 more desirable in terms of fertility rate, but use of catgut sutures and splints was associated with increased adhesion formation, fibrosis, and poor healing of the surgical anastomosis wound. Adhesions are thought to be caused by blood clots; hence care in handling of tissue during reconstructive microsurgery is emphasized in this technique.
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