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  • Title: Biosynthesis of flaviolin and 5,8-dihydroxy-2,7-dimethoxy-1,4-naphthoquinone.
    Author: McGovern EP, Bentley R.
    Journal: Biochemistry; 1975 Jul 15; 14(14):3138-43. PubMed ID: 1148193.
    Abstract:
    Tracer experiments indicate a polyketide origin for the production of flaviolin (2,5,7-trihydroxy-1,4-naphthoquinone) by Aspergillus niger and 2,7-dimethoxynaphthazarin (5,8-dihydroxy-2,7-dimethoxy-1,4-naphthoquinone) by Streptomyces no. 12396. With the Streptomycete, a "solid state fermentation" technology was used for the incorporation studies. Radioactivity from shikimic acid was effectively incorporated into flaviolin; this conversion, however, proceeded by way of acetic acid. The latter stages of biosynthesis of 2,7-dimethoxynaphthazarin by the Streptomycete were shown to be as follows: flaviolin leads to mompain leads to 2,7-dimethoxynaphthazarin.
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