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  • Title: M1 receptor activation is a requirement for arecoline analgesia.
    Author: Ghelardini C, Galeotti N, Lelli C, Bartolini A.
    Journal: Farmaco; 2001; 56(5-7):383-5. PubMed ID: 11482763.
    Abstract:
    Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.). A dose-dependent inhibition of the antinociception induced by arecoline was observed after inactivation of the M1 gene by an antisense oligodeoxyribonucleotide (aODN). This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors.
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