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  • Title: Long-term effects on the intelligence of children treated for acute lymphoblastic leukemia.
    Author: Kolotas C, Daniel M, Demetriou L, Martin T, Kurek R, Tonus C, Göbel U, Schnabel T, Zamboglou N.
    Journal: Cancer Invest; 2001; 19(6):581-7. PubMed ID: 11486700.
    Abstract:
    The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used was the Hamburg Weschsler Intelligence Test for Adults. The IQ results did not differ significantly, p > 0.05, from the IQs of the general population. It was found that age and dose were not predictors of a decrease in IQ. The only predictor was time lapse between irradiation and IQ measurement, which we found to be indicative of an IQ decrease even after 9 years. Time lapse between irradiation is a useful predictor of IQ.
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