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  • Title: Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset.
    Author: Tamura T, Igarashi O, Hino A, Yamane H, Aizawa S, Kato T, Nariuchi H.
    Journal: J Immunol; 2001 Aug 15; 167(4):1962-9. PubMed ID: 11489976.
    Abstract:
    We previously showed that the amounts of Fyn protein in Th2 clones were approximately one-third to one-fifth of those in Th1 clones. In this study we examined the role of Fyn in the polarization of naive CD4+ T cells toward the Th2 subset using fyn(-/-) mice. The fyn(-/-) naive CD4+ T cells efficiently produced Th2 cytokines and polarized toward the Th2 subset even in the absence of IL-4 and IL-13. The expression of Fyn in wild-type CD4+ T cells decreased at a transcription level concomitant with polarization toward the Th2 subset. These results suggest that Fyn plays a role in the down-regulation of the differentiation of naive CD4+ T cells into the Th2 subset.
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