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  • Title: [Circadian rhythms of hemodynamic load on the cardiovascular system in patients with essential hypertension: implication for drug therapy rationale].
    Author: Komarov FI, Ol'binskaia LI, Khapaev VA.
    Journal: Klin Med (Mosk); 2001; 79(3):52-5. PubMed ID: 11490420.
    Abstract:
    Circadian rhythm of hemodynamic load by double product (heart rate x systolic blood pressure) was studied in 224 patients with essential hypertension (EH) treated with different antihypertensive drugs for 8-12 weeks and in 23 healthy subjects. The main feature of the rhythm was a marked morning rise in all the patients including non-dippers and night-peakers without nocturnal blood pressure fall. The examined drugs showed different effects on mean 24-h and morning values of the double product.
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