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  • Title: Comparative study on the use of co-trimoxazole and tetracycline in the treatment of lower respiratory tract infections.
    Author: Sallam MA, Sallam IA.
    Journal: Curr Med Res Opin; 1975; 3(4):229-31. PubMed ID: 1149490.
    Abstract:
    A double-blind trial was carried out on 116 patients with lower respiratory tract infection and systemic manifestations. One group received co-trimoxazole (480 mg. trimethoprim and 2,400 mg. sulphamethoxazole daily), and the other group received 2 g. tetracycline daily. The trial, as judged by clinical improvements, the reduction of purulent sputum and the rate of eradication of infection, showed a better result with co-trimoxazole. The incidence of side-effects were higher in the group receiving tetracycline compared with those receiving co-trimoxazole.
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