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  • Title: Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice.
    Author: Johanning GL, Cope MB, Wilborn T, Grubbs CJ, Lubet RA.
    Journal: Anticancer Res; 2001; 21(3B):1691-5. PubMed ID: 11497248.
    Abstract:
    The expression of retinoid receptors is altered during the development of several types of cancer. In the present study, we determined the influence of high dietary concentrations of 4-hydroxyphenylretinamide (4-HPR) and 13-cis-retinoic acid (13-cis-RA) on RAR-beta mRNA expression in female mice. Expression of liver and lung RAR-beta RNA increased with increasing levels of dietary retinoid (both 4-HPR and 13-cis RA). Bladder RAR-beta mRNA levels, however, were significantly decreased in mice fed 13-cis RA or 4-HPR. These results suggest that feeding high levels of retinoids to mice results in tissue-specific elfects on expression of RAR-beta mRNA.
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