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  • Title: [Research on substances with antiblastic activity. LVIII. Synthesis and antineoplastic activity of derivatives of pyrrolo-(1,2-a)quinoxaline].
    Author: De Martino G, Massa S, Scalzo M.
    Journal: Farmaco Sci; 1975 Jul; 30(7):581-90. PubMed ID: 1149884.
    Abstract:
    Some derivatives of pyrrolo[1,2-a]quinoxaline and 7,8-dimethoxypyrrolo[1,2-a]quinoxaline, structurally related to two antitumoral antibiotics, mitomycin C and anthramycin, have been prepared. The synthesis of the two nuclei was carried out starting from the required nitroaniline and 2,5-diethoxytetrahydrofuran; formylation of the pyrrole derivative and successive reduction gave the heterocyclic compound directly. Antineoplastic activity was evaluated on mice treated intraperitoneally with leukemia L 1210.
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