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  • Title: [Role of M-type receptor in internal calcium release and quantal secretion in rat adrenal chromaffin cells].
    Author: Xu JH, Zeng XH, He LM, Qu AL, Zhou Z.
    Journal: Sheng Li Xue Bao; 1999 Oct; 51(5):564-70. PubMed ID: 11498955.
    Abstract:
    In rat single adrenal chromaffin cells, the effects of methacholine (MCh) on [Ca2+]i and catecholamine secretion were studied with fura-2 fluorescence and carbon fiber electrodes. In the presence of 2 mmol/L Ca2+ in the bath, locally applying 1 mmol/L MCh, either containing or not containing Ca2+, evoked both [Ca2+]i and secretion signals. In the absence of Ca2+ in the bath, MCh could still evoke [Ca2+]i and secretion. These results suggest that MCh causes release of Ca2+ from Ca2+ stores, which is sufficient to yield the evoked secretion. The Ca2+ store can be depleted by single MCh puff in the absence of Ca2+ in the bath.
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