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  • Title: [Allergens adsorbed on aluminum hydroxide preparation, standardization controls and therapeutic results].
    Author: Relyveld EH, Henocq E.
    Journal: Dev Biol Stand; 1975; 29():295-307. PubMed ID: 1149938.
    Abstract:
    Specific desensitizing treatments with house dust extract purified and adsorbed on aluminium hydroxyde gave 79% good and very good results in 355 patients. Grass pollen extracts adsorbed on the same adjuvant gave 76% good and very good results in 166 patients. Desensitization by the adsorbed preparations requires fewer injections than the usual methods, while offering security by the absence of anaphylactic reactions, particularly with pollen extracts. The activity of the preparations is tested after appropriate dilution, taking account of the total nitrogen content of the dust extracts and the weight of raw materials used in the manufacture of the pollen extracts. The results of the intradermal tests undertaken with fluid preparations and compared with those obtained with a standard preparation allow to standardize the allergenic activity of the extracts. It is thus possible to guarantee the pharmaceutical quality of the allergens both for diagnostic tests and for treatments. Chemical analyses and control of acute, delayed or chronic toxicity ensure the innocuousness of the preparations.
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