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Title: Sympathectomy induces novel purinergic sensitivity in sciatic afferents. Author: Chen Y, Zhang YH, Bie BH, Zhao ZQ. Journal: Acta Pharmacol Sin; 2000 Nov; 21(11):1002-4. PubMed ID: 11501053. Abstract: AIM: To test the hypothesis that sympathectomy could induce novel purinergic sensitivity in sciatic afferents. METHODS: Teased-fiber recordings were made from 32 spontaneously active A afferents from the sciatic nerves in surgically sympathectomized rats and 30 spontaneously active A afferents from the sciatic nerves in intact rats. Adenosine 5'-triphosphate (ATP) was injected via a cannula in jugular vein. RESULTS: Twenty eight percent of the spontaneously active afferent fibers from sciatic nerves in the sympathectomized rats responded to ATP, either with an increase or with a decrease in spontaneous firing. However, none of the fibers from the sciatic nerves in the intact rats was activated by ATP. CONCLUSION: Sympathectomy induces novel purinergic sensitivity in A afferents from sciatic nerve.[Abstract] [Full Text] [Related] [New Search]