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  • Title: Determination of serum cytokines in individuals with HCV infection.
    Author: Fan X, Liu W, Li C.
    Journal: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 2000 Jun; 14(2):145-7. PubMed ID: 11503046.
    Abstract:
    OBJECTIVE: To investigate the immunopathogenesis of chronic hepatitis C virus (HCV) infection. METHODS: Serum T-helper lymphocyte (Th1) cytokines (IFN-gamma, IL-2) and Th2 cytokines (IL-4, IL-10) were measured by ELISA in 18 individuals with chronic HCV infection 10 persons of chronic HBV infection and 11 normal persons. RESULTS: IL-2 (P <0.05), IL-4 and IL-10 (P <0.025, P <0.001) were significantly increased in HCV infected hosts as compared to 11 normal controls, the production of Th2 cytokines was more predominant. CONCLUSIONS: An enhanced Th2 responses is present in HCV infection, which may he responsible for the chronicity of HCV infection.
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