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  • Title: [Endothelin-1 in pathogenesis of Raynaud's syndrome].
    Author: Knapik-Kordecka M, Adamiec R, Ciosek W.
    Journal: Pol Merkur Lekarski; 2001 Jun; 10(60):424-5. PubMed ID: 11503255.
    Abstract:
    Endothelin is an endogenous vasoconstrictor and plays an important role in pathogenesis of Raynaud's phenomenon. Plasma endothelin-1 (ET-1) and von Willebrand factor (vWF) concentrations following cold exposure in 52 patients with Raynaud's phenomenon were measured. Statistically significant increase of ET-1 and vWF was found in the study group in compare to healthy volunteers. There was positive correlation between ET-1 and vWF in those cases. The dates suggest that ET-changes indicates a vasospastic effect on vascular injury. Treatment with endothelin-receptor antagonist may prevent structural changes in vessel well.
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