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  • Title: Microbial transformation of validamycins.
    Author: Kameda Y, Horii S, Yamano T.
    Journal: J Antibiot (Tokyo); 1975 Apr; 28(4):298-306. PubMed ID: 1150529.
    Abstract:
    Alpha- or beta-Glucosidic linkage of validamycin was selectively cleaved by microbial hydrolysis and especially the conversion of validamycin C into validamycin A by the selective hydrolysis of alpha-glucoside linkage has important significance because validamycin C is considerably less active than validamycin A. Semisyntheses of validamycins including a new validamycin, beta-D-galactosyl-validoxylamine A were carried out by microbial transglycosidation using validoxylamine A as a glycosyl acceptor. D-[U-14C]glucose and [14C]validoxylamine A were highly incorporated into validamycin A by validamycin-producing Streptomyces hygroscopicus var. limoneus.
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