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  • Title: Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: establishment of structure-activity relationships.
    Author: Apers S, Baronikova S, Sindambiwe JB, Witvrouw M, De Clercq E, Vanden Berghe D, Van Marck E, Vlietinck A, Pieters L.
    Journal: Planta Med; 2001 Aug; 67(6):528-32. PubMed ID: 11509973.
    Abstract:
    Ten saponins isolated from the leaves of Maesa lanceolata were tested for their antiviral, haemolytic and molluscicidal activities. The influence of the substitution pattern of these acylated triterpenoid saponins on their biological activities was investigated and structure-activity relationships were established. Maesasaponin VI(2) (3 beta-O-[[alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-galactopyranosyl-(1 --> 3)]-[beta-D-galactopyranosyl-(1 --> 2)]-beta-D-glucopyranuronyl]-21 beta,22 alpha-diangeloyloxy-13 beta,28-epoxyolean-16 alpha,28 alpha-diol), the most potent molluscicidal compound (LC(50) 0.5 ppm), also showed virucidal and haemolytic activity. In general, 21,22-diacylation appeared to be associated with a virucidal (reduction factor of the viral titer > or = 10(3) at 50 microg/ml) and haemolytic activity (HC(50) < or = 1 microg/ml).
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