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  • Title: Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF-7 cells.
    Author: Hu CC, Tang CH, Wang JJ.
    Journal: FEBS Lett; 2001 Aug 10; 503(1):65-8. PubMed ID: 11513856.
    Abstract:
    Rana catesbeiana ribonuclease (RC-RNase) and onconase were proven to own anti-tumor activity. While molecular determinants of onconase-induced cell death have become more explicit, the RC-RNase-induced death pathway remains presently unknown. Here we demonstrated that RC-RNase-induced molecular cascades in caspase-3-deficient MCF-7 cells did not include activation of initiation caspase-8 and -9. Cleavage timing suggested that procaspase-2 and -6 might be processed by active caspase-7 in MCF-7 cells. Caspase-7 was also responsible for cleavage of the poly(ADP-ribose) polymerase. Furthermore, we reported that overexpression of Bcl-X(L) could raise the survival rates of MCF-7 cells treated with RC-RNase and onconase.
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